Couple of weeks ago, one of my former coworkers ran across a very weird problem when he was prototyping on some of his ideas with ASP.NET Web API: No HTTP resource was found that matches the request URI. Let's see what this issue was all about and what is the solution.
OWIN (8)

I've recorded a short video which covers the brief introduction of OWIN and Project Katana. That short video will give you an idea about OWIN and Project Katana.

This post will show you how to you can replace the default server of OwinHost.exe with Nowin in Visual Studio 2013

Microsoft implementation of OWIN (Microsoft.Owin or Katana for now) has a great logging infrastructure and this post will walk you through the basics of this component.

With Visual Studio 2013 RC, we are introduced to a new extensiblity point: External Host. This gives us the F5 experience Wwth OwinHost.exe on VS 2013 and this post walks you through this feature.

Owin.Dependencies is an IoC container adapter into OWIN pipeline. This post will walk you through the Autofac IoC container implementation and ASP.NET Web API framework adapter for OWIN dependencies.
I was at Microsoft's Turkey headquarters giving talks on Microsoft Web Stack for Microsoft Summer School and here are presentation samples and links for .NET Web Stack

OWIN and Katana is best way to build web server indipendent web applications in .NET ecosystem and this post will help you a bit on getting started.